The history of Ukraine, a country located in Eastern Europe and which achieved independence in 1991 following the dissolution of the Soviet Union, is marked by profound divisions: linguistic, political, and above all, by those produced by the events of the last 100 years. All of these have made it fertile terrain for the hatching of internal conflicts, which these days has become the mindset of its successive governments and its people. In this chapter, an analysis is made of the conflict between Ukraine and the separatist forces of Donetsk and Lugansk, in which Russia plays a leading and decisive role. In addition to studying the strategy of the two warring parties on Ukranian territory, as well as that of Russia, there will also be a study of the determinant role being carried out by major external actors, especially the U.S., the European Union and NATO.